Marcella Puppini started playing the piano at age five, and hoped to become an opera singer. At the age of 18, having completed her A levels in Classics (Ancient Greek, Latin, Italian Literature and Art History), Puppini moved to London to study at Central Saint Martins College of Art and Design. Having graduated in fashion, Puppini went on to become Accessories Production Manager at Vivienne Westwood Studios, but kept her side career as a singer in clubs all around London.
Her first band was called Dead Sex Kitten. Puppini guested on Rich B’s song "Revolution". She also performed in her own name in the jazz and cabaret scene both in the UK and in Italy.
In 1999, she left the fashion world and embarked on a degree course at Trinity College of Music, where she graduated in Jazz Performance and Composition.
In 2004, Puppini created a new group called the Puppini Sisters: a close-harmony trio inspired by the sister groups of the ‘30s and ‘40s. The Puppini Sisters debut album, Betcha Bottom Dollar , was awarded a Gold disc in the UK.
Puppini became involved in the alternative performance art scene. She worked with Marisa Carnesky on Ghost Train, with Paloma Faith in 2005, with The Whoopee Club as musical Director, and with Duckie.
She later founded Marcella and The Forget Me Nots. The band’s first official release came out in January 2010, as part of Twisted Cabaret, a part-audio, part-video compilation curated by French label Volvox. Marcella and The Forget Me Nots changed formation in 2010 to become an indie-art-punk-Weimar inspired band, and released Born Beautiful in 2011.
Puppini has also been working as a regular guest conductor for the Russian jazz big band, The Georgy Garanian Big Band, formerly known as the Russian State Big Band. She has performed in Moscow, and also in Siberia and in Izhevsk as part of a Tchaikovsky festival.
In May 2013, Puppini was nominated as the Mayoress of Camden.